 | Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine Bio-Instructive Scaffolds for Musculoskeletal Tissue Engineering and Regenerative Medicine explores musculoskeletal tissue growth and development across populations, ranging from elite athletes to the elderly. The regeneration and reparation of musculoskeletal tissues present the unique challenges of requiring both the need to withstand distinct forces applied to the body and ability to support cell populations. The book is separated into sections based on tissue type, including bone, cartilage, ligament and tendon, muscle, and musculoskeletal tissue interfaces. Within each tissue type, the chapters are subcategorized into strategies focused on cells, hydrogels, polymers, and other materials (i.e. ceramics and metals) utilized in musculoskeletal tissue engineering applications. In each chapter, the relationships that exist amongst the strategy, stem cell differentiation and somatic cell specialization at the intracellular level are emphasized. Examples include intracellular signaling through growth factor delivery, geometry sensing of the surrounding network, and cell signaling that stems from altered population dynamics. Justin L. Brown is an Associate Professor of Biomedical Engineering at The Pennsylvania State University whose research interests are understanding the intracellular mechanisms that govern the response of stem cells to extracellular geometries, and developing bio-instructive scaffolds for musculoskeletal regenerative medicine based on these intracellular geometery sensing mechanisms. Sangamesh G. Kumbar an Assitant Professor of Orthopaedic Surgery, Biomedical Engineering, and Materials Science and Engineering at the University of Connecticut whose research is focused on synthesis and characterization of novel biomaterials for tissue engineering and drug delivery applications. Brittany L. Banik is a Graduate Research Assistant in Bioengineering at The Pennsylvania State University with particular interests in Nanomedicine, Mechanobiology, and Regenerative Medicine. |
