Biological Small Angle Scattering: Theory and Practice
ISBN: 9780191749575
Platform/Publisher: Oxford Academic / Oxford University Press
Digital rights: Users: Unlimited; Printing: Unlimited; Download: Unlimited
Subjects: Condensed Matter Physics Biological and Medical Physics;

Small angle solution scattering (SAS) is increasingly being applied to biological problems. It is a complementary technique that, when applied in appropriate circumstances with carefully structured questions, can provide unique information not available from other techniques. While small angle solution scattering has been around for some time, a confluence of recent developments has dramatically enhanced its power. Intense third generation X-ray sources, low noise detectors, development of new algorithms and the computational power to take advantage of these have all matured, and use of free-electron x-ray laser sources is on the horizon. Whole new classes of experiments and analyses have been created as a result. These include the generation of molecular envelopes, the ability to do time-resolved studies, and the ability to account for structural changes using modelling based on the SAS data. The technical improvements have also reduced the amount of time and material needed to carry out an experiment. Beamtime at synchrotron sources is in demand, workshops on the subject are popular and researchers adopting the technique as part of their repertoire are growing. With these in mind, this book was written to guide structural biologists who may wish to adopt the technique, understand its strengths and weaknesses or just have a general interest in its potential.


Eaton E. Lattman, Professor of Structural Biology, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Thomas D. Grant, Staff Scientist, BioXFEL Science and Technology Center, School of Medicine and Biomedical Sciences, University at Buffalo, SUNY, Edward H. Snell, President and Chief Executive Officer, Hauptman-Woodward Medical Research Institute

Eaton Lattman received a BA degree from Harvard College in Chemistry and Physics, and a PhD degree from the Johns Hopkins University in Biophysics. He went on to spend many years at Johns Hopkins, rising through the ranks to become Professor, Departmental Chair, and Dean of Research and Graduate Education. He is currently Professor of Structural Biology in the School of Medicine and Biomedical Sciences, University at Buffalo, SUNY. He has published many papers in the area of structural biology, including a number on methods development.



Thomas Grant received a B.S. degree from the University at Buffalo in Mathematical Physics and a PhD from the University at Buffalo in Structural Biology. After a post-doc at the Hauptman-Woodward Institute, he became a Staff Scientist as part of the NSF Science and Technology Center known as BioXFEL through the University at Buffalo.

Edward Snell received a B.Sc. Hons. Degree from the John Moore University of Liverpool, UK, in Applied Physics and a Ph.D. from the University of Manchester, UK, in the Chemistry Department. He was a National Science Foundation Research Fellow at the NASA Laboratory for Biophysics at Marshall Space Flight Center in Huntsville, Alabama, USA and later as a staff scientist in the same laboratory. Since 2005, he has been at the Hauptman-Woodward Medical Research Institute in Buffalo NY and serves as the current President and Chief Executive Officer.

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