Ebooks for the Classroom+Faculty

Sequence Alignment: Methods, Models, Concepts, and Strategies
ISBN: 9780520943742
Platform/Publisher: Oxford Academic / University of California Press
Digital rights: Users: Unlimited; Printing: Unlimited; Download: Unlimited
Subjects: Bioinformatics and Computational Biology Genetics and Genomics Research Methods in Life Sciences Evolutionary Biology;

The sequencing of the human genome involved thousands of scientists but used relatively few tools. Today, obtaining sequences is simpler, but aligning the sequences--making sure that sequences from one source are properly compared to those from other sources--remains a complicated but underappreciated aspect of comparative molecular biology. This volume, the first to focus on this crucial step in analyzing sequence data, is about the practice of alignment, the procedures by which alignments are established, and more importantly, how the outcomes of any alignment algorithm should be interpreted. Edited by Michael S. Rosenberg with essays by many of the field's leading experts, Sequence Alignment covers molecular causes, computational advances, approaches for assessing alignment quality, and philosophical underpinnings of the algorithms themselves.

Michael S. Rosenberg is Associate Professor of Computational Evolutionary Biology and Bioinformatics in the School of Life Sciences and the Center for Evolutionary Functional Genomics of the Biodesign Institute at Arizona State University.