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| An Introduction to Toxicogenomics
ISBN: 9780429211089
Platform/Publisher: Taylor & Francis / CRC Press
Digital rights: Users: Unlimited; Printing: Unlimited; Download: Unlimited
Subjects: Bioscience; Toxicology; Biology; Pharmaceutical Science; Genetics; Drug Design & Development;
Since the advent of cDNA microarrays, oligonucleotide array technology, and gene chip analysis, genomics has revolutionized the entire field of biomedical research. A byproduct of this revolution, toxicogenomics is a fast-rising star within toxicological analysis. Gathering together leading authors and scientists at the forefront of the field, An Introduction to Toxicogenomics provides a comprehensive overview of this new discipline. With a focus on toxicology, it introduces the basic principles of microarray/oligonucleotide array-based genomic analysis and explains how it fits into the field of biomedical research. These discussions provide an overview to the actual mechanics of the analyses themselves and offer insights on handling and quality control. Then the book features an important section on the basics of data analysis and clustering methods such as genetic algorithms. Finally, it covers the application of expression profiling in the field of toxicology and addresses the two fundamental types of analysis in detail, with sections dedicated to both mechanistic and predictive studies. Although toxicogenomics promises fast, efficient techniques and information-rich data, much of its potential remains untapped. An Introduction to Toxicogenomics consolidates the concepts underlying the field to provide a solid foundation from which to begin your research endeavors.
Dr. Michael Burczynski received his Ph.D. in Phannacology from the University of Pennsylvania and is currently an investigator in the Division of Molecular Medicine at Wyeth Research in Cambridge, MA. Some of his most recent articles have appeared in the scientific journals Toxicological Sciences, Cancer Research, Biochemistry, and The Journal of Biological Chemistry. He received a Bristol Myers Squibb Young Investigator Award in 1999 from the American Association of Cancer Research for his work on the role of human aldo-keto reductases in oxidative stress. He is a member of the American Association of Cancer Research, the Society of Toxicology, and several other professional organizations. He has resided in various locales, including Idaho, London, Philadelphia, New York, and Boston. His interests include classical piano, hockey, golfing, falconry, and flyfishing with his father in the Catskill Mountains in upstate New York. He is also a novelist and writes under the pen name Michael St. Clair. He is currently at work finishing up his first two novels: a biomedical thriller entitled The Apocalypse Gene and a serial killer mystery entitled The Pain Resurrector. |
